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KMID : 0605719980040010036
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Journal of the Korean Society of Biological Therapies in Psychiatry
1998 Volume.4 No. 1 p.36 ~ p.44
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Eye Tracking Abnormality in First-degree Relatives of Schizophrenic Patients
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장진열/Jin Youl Jang
정원후/김종현/우성일/김성부/Won Hu Jung/Jong Hyon Kim/Sung Il Woo/Sung Boo Kim
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Abstract
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Eye tracking abnormality has been found in large numbers of first-degree relatives of
schizophrenic patients. Eye tracking abnormality, one of the reliable biological markers in
schizophrenia. There for the author examined eye tracking abnormality, power spectral
density curves and Ln S/N ratios in 44 first-degree relatives of schizophrenic patients
and 41 normal controls. The results as follows.
1. The Ln S/N ratios of first-degree relatives of schizophrenic patients in pursuit eye
tracking was significantly lower that of normal controls(p<0.05).
2. The Ln S/N ratios of biological parents of schizophrenic patients in pursuit eye
tracking showed lower tendency than those of normal controls of parents, but it was
not significant. The Ln S/N ratios of biological siblings of schizophrenic patients in
pursuit eye tracking showed lower tendency than those of normal controls of siblings,
but it was not significant.
3. There was no correlation between pursuit eye tracking and age(r=0.073, p=0.446).
In conclusion, the author suggest by the results of this study that eye tracking
abnormality of the first-degree relatives in schizophrenic patients can be assessed
globally and quantitatively by the Ln S/N ratio, and propose as a useful way of
expanding the schizophrenia phenotype in genetic studies.
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